As part of the Behavioral Science Immunization Network (BeSIN) project, JSI and the Ghana Health Service collaborated to identify persistent vaccine acceptance and demand challenges where behavioral science could be applied to overcome them. The Ghana Health Service and its partners identified low COVID-19 vaccine uptake, particularly in urban communities, as a major challenge. According to Ghana Health Service administrative data from June 2022, Ga South was one of 167 districts where between 25-49.9% of the eligible population were fully vaccinated against COVID-19 and was also among the 10 districts with the highest number of unvaccinated children. For these reasons, Ga South was chosen as an ideal location to test different behavioral science approaches and processes to support its goals of improving uptake and coverage of COVID-19 vaccines in the district.