Adolescence represents a sensitive time period during an individual’s development during which physical, psychological, and social risk factors for non-communicable diseases are established. As such, there is a necessity to engage adolescents in planning and decision-making processes that will affect their future health. This paper describes the need for more innovative and transversal actions, starting from the utility of a multidisciplinary and systemic approach to health. One way in which this can be achieved is by shifting adolescent health programs (AHPs) from a clinically oriented to an education-based model. In particular, AHPs need to consider a personalized and systemic approach to the well-being of adolescents in order to potentiate their strengths and improve weaknesses, enhancing self-esteem, empowerment, and resilience.